State Street becomes substantial holder in Mesoblast Limited

State Street Corporation and its subsidiaries have become a substantial holder in Mesoblast Limited (ASX:MSB) as of October 27, 2025. The group now holds a relevant interest in 64,604,775 ordinary shares, representing 5.04% of the voting power in Mesoblast Limited.

The relevant interests are held by various State Street entities, including State Street Global Advisors Europe Limited, State Street Bank and Trust Company, State Street Global Advisors Trust Company, SSGA Funds Management, Inc., State Street Global Advisors Limited, and State Street Global Advisors, Australia, Limited. These interests primarily stem from the power to control the exercise of voting rights and/or the power to dispose of securities as an investment manager or trustee.

Significant transactions contributing to this holding include multiple acquisitions and disposals of ordinary shares between June 27, 2025, and October 27, 2025. For instance, State Street Bank and Trust Company acquired 2,450,000 ordinary shares on July 1, 2025, and 922,896 ordinary shares on July 4, 2025. The consideration for these transactions included both cash and non-cash elements.