Dr. William Gueck and State Street become substantial holders in Mesoblast

Hamilton Locke, on behalf of Dr. William Gueck, announced that Dr. Gueck became a substantial holder in Mesoblast Limited on September 12, 2025. Dr. Gueck's total voting power stands at 5.01%, representing 64,171,900 ordinary fully paid shares. This holding is comprised of direct and indirect interests, including shares held jointly with Conrad and Ava Gueck, various irrevocable trusts, and significant holdings through COVA Holdings LP and AVCO Holdings LP. Acquisitions in the preceding four months were primarily "on market purchase of ADRs," with various transactions detailed across July and August 2025 for multiple associated entities, including Ava Gueck and William Gueck, AVCO Holdings LP, COVA Holdings LP, and William J Gueck Irrevocable Trust.

Separately, State Street Corporation and its subsidiaries also became a substantial holder in Mesoblast Limited on September 12, 2025, with a voting power of 5.01%, corresponding to 64,167,452 ordinary shares. State Street's relevant interests stem from its capacity as investment manager or trustee for various entities, as well as roles in securities lending agreements. Their acquisitions over the past four months involved numerous "on market" purchases and other transactions, as detailed across the extensive Annexure A, B, and C forms.